MD. Physician, Department of Emergency Medicine, Ankara City Hospital, Ankara, Turkey.
MD. Physician, Department of Medical Biochemistry, Karadeniz Ereğli State Hospital, Zonguldak, Turkey.
Sao Paulo Med J. 2022 May-Jun;140(3):378-383. doi: 10.1590/1516-3180.2021.0066.R2.16082021.
Effective triage and early detection are very important for controlling and treating coronavirus disease 2019 (COVID-19). Thus, the relationships between hypoalbuminemia and other acute-phase reactants in such cases need to be evaluated.
To investigate the importance of albumin levels in cases of severe pneumonia due to COVID-19.
Prospective study conducted in Ankara City Hospital (a stage 3 hospital), Turkey.
Data from 122 patients diagnosed with pneumonia due to COVID-19 who were admitted to this hospital were analyzed statistically in comparison with date from 60 healthy controls. Three groups were established: healthy controls, intubated patients and non-intubated patients. Lung tomography scans from the patients were examined one-by-one. Real-time polymerase chain reaction (RT-PCR) test results were recorded.
Albumin levels were statistically significantly lower in the intubated and non-intubated groups than in the control group, in comparing the three groups (P < 0.01). The other acute-phase reactants, i.e. neutrophil-to-lymphocyte ratio and C-reactive protein levels, were significantly higher in the intubated and non-intubated groups than in the control group (P < 0.05). Albumin levels were also significantly lower in the intubated group than in the non-intubated group (P = 0.02). No differences were detected with regard to other parameters (P > 0.05).
Hypoalbuminemia may constitute a biomarker indicating the severity of pneumonia due to COVID-19.
有效分诊和早期检测对于控制和治疗 2019 年冠状病毒病（COVID-19）非常重要。因此，需要评估此类病例中低白蛋白血症与其他急性期反应物之间的关系。
研究白蛋白水平在 COVID-19 所致重症肺炎中的重要性。
在土耳其安卡拉城市医院（三级医院）进行的前瞻性研究。
对该院收治的 122 例 COVID-19 肺炎患者的临床资料进行统计分析，并与 60 例健康对照者进行比较。将患者分为三组：健康对照组、插管组和非插管组。对患者的肺部 CT 扫描进行逐一检查，记录实时聚合酶链反应（RT-PCR）检测结果。
与对照组相比，插管组和非插管组患者的白蛋白水平明显更低，三组之间差异具有统计学意义（P < 0.01）。与对照组相比，插管组和非插管组的其他急性期反应物，即中性粒细胞与淋巴细胞比值和 C 反应蛋白水平明显更高（P < 0.05）。与非插管组相比，插管组的白蛋白水平也明显更低（P = 0.02）。其他参数无差异（P > 0.05）。
低白蛋白血症可能是 COVID-19 所致肺炎严重程度的生物标志物。
