Tianjin Key Laboratory of Indoor Air Environmental Quality Control, School of Environmental Science and Engineering, Tianjin University, Yaguan Road 135, Jinnan District, Tianjin, 300350, China.
Tianjin Key Laboratory of Indoor Air Environmental Quality Control, School of Environmental Science and Engineering, Tianjin University, Yaguan Road 135, Jinnan District, Tianjin, 300350, China.
Chemosphere. 2022 Sep;302:134786. doi: 10.1016/j.chemosphere.2022.134786. Epub 2022 May 1.
Prevalences of allergies and asthma have increased through the past few decades around the world, especially in countries and regions that have adopted modern lifestyles. Epidemiological studies outside of China have found a relationship between phthalates concentrations in indoor dust and symptoms of respiratory, skin and nose allergies. The aim of our study is to investigate the association between children's asthma and allergic symptoms and concentrations of different phthalates in settled dust samples collected from children's homes in metropolitan Tianjin (Tianjin and Cangzhou), China. We selected 126 cases with current allergic symptoms and 254 controls without allergic symptoms from the cohort of 7865 children. We collected dust samples from children's bedroom and analyzed them for their content of diethyl phthalate (DEP), diisobutyl phthalate (DiBP), di-n-butyl phthalate (DnBP), butylbenzyl phthalate (BBzP), di-2-ethylhexyl phthalate (DEHP) and diisononyl phthalate (DiNP). We found a higher concentration of DEP in rhinitis children's homes (0.33 vs. 0.27 μg/g dust) and a higher concentration of DiBP in asthma children's homes (29.04 vs. 15.66 μg/g dust). The concentration of DiBP was significantly associated with diagnosed asthma (adjusted odds ratio (AOR): 1.30; 95% confidence interval (CI): 1.07, 1.57). A dose-response relationship was found between concentrations of DiBP in dust and asthma. This study shows that some phthalates are associated with allergic and asthma symptoms in children.
过去几十年，全球范围内过敏和哮喘的患病率不断上升，尤其是在采用现代生活方式的国家和地区。中国以外的流行病学研究发现，室内灰尘中邻苯二甲酸酯浓度与呼吸道、皮肤和鼻子过敏症状之间存在关联。本研究旨在调查天津市（天津和沧州）城区儿童家中采集的积尘样本中不同邻苯二甲酸酯浓度与儿童哮喘和过敏症状之间的关系。我们从 7865 名儿童的队列中选择了 126 例有当前过敏症状的病例和 254 例无过敏症状的对照。我们从儿童卧室采集灰尘样本并对其邻苯二甲酸二乙酯（DEP）、邻苯二甲酸二异丁酯（DiBP）、邻苯二甲酸二正丁酯（DnBP）、邻苯二甲酸丁基苄基酯（BBzP）、邻苯二甲酸二（2-乙基己基）酯（DEHP）和邻苯二甲酸二异壬酯（DiNP）的含量进行了分析。我们发现，鼻炎儿童家中的 DEP 浓度较高（0.33 vs. 0.27 μg/g 灰尘），哮喘儿童家中的 DiBP 浓度较高（29.04 vs. 15.66 μg/g 灰尘）。DiBP 浓度与确诊哮喘显著相关（调整后的优势比（AOR）：1.30；95%置信区间（CI）：1.07，1.57）。我们还发现灰尘中 DiBP 浓度与哮喘之间存在剂量反应关系。本研究表明，某些邻苯二甲酸酯与儿童的过敏和哮喘症状有关。
