Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran.
Leuk Lymphoma. 2022 Aug;63(8):1949-1955. doi: 10.1080/10428194.2022.2056174. Epub 2022 May 4.
Anti-cancer properties of vitamin D have been reported in studies. The aim of this study was to evaluate the expression of some key enzymes involved in vitamin D metabolism and the serum levels of related proteins. Fifty-four patients with acute myeloid leukemia (AML) and 55 eligible individuals were studied as the control group. The expression of VDR, CYP27B1, and CYP24A1 genes was measured. Serum levels of related proteins were quantified. The association between the studied variables and treatment outcomes: duration of fever and neutropenia, length of hospital stay, achievement of complete remission and overall survival has been investigated. Expression of CYP24A1 gene and serum levels of CYP27B1 and CYP24A1 proteins were significantly higher in the patient group. CYP24A1 gene expression, its blood concentrations and serum levels of CYP27B1 were significantly higher in the AML group. Vitamin D status and key enzymes did not show a strong change in AML patients neither did associate with treatment outcomes except CYP24A1.
已有研究报道维生素 D 具有抗癌特性。本研究旨在评估维生素 D 代谢中一些关键酶的表达及相关蛋白的血清水平。选取 54 例急性髓系白血病（AML）患者和 55 例符合条件的个体作为对照组。测量 VDR、CYP27B1 和 CYP24A1 基因的表达。定量检测相关蛋白的血清水平。研究了所研究变量与治疗结果（发热和中性粒细胞减少的持续时间、住院时间、完全缓解的实现和总生存率）之间的关系。患者组 CYP24A1 基因表达、CYP27B1 和 CYP24A1 蛋白的血清水平显著升高。AML 组 CYP24A1 基因表达、其血液浓度和 CYP27B1 的血清水平显著升高。维生素 D 状态和关键酶在 AML 患者中没有明显变化，除 CYP24A1 外，与治疗结果也没有相关性。
