Department of Rehabilitation Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
Department of Rehabilitation Medicine, Iwate Medical University, Morioka, Japan.
Spinal Cord. 2022 Nov;60(11):978-983. doi: 10.1038/s41393-022-00788-9. Epub 2022 May 4.
Experimental study.
To compare lipid metabolism in individuals with a cervical spinal cord injury (SCI) and able-bodied (AB) persons in response to mild cold stress.
Laboratory of Wakayama Medical University, Japan.
Nine males with SCI and 11 AB wore a water-perfusion suit in a supine position. Following 30-min rest thermoneutrality, the whole body was cooled by perfusing 25 °C water through the suit for 15-20 min (CS). Blood samples were collected before, immediately, and 60 (post-CS60) and 120 min after CS (post-CS120). Concentrations of serum free fatty acid ([FFA]), total ketone bodies ([tKB]), insulin ([Ins]) and plasma adrenaline ([Ad]), noradrenaline ([NA]) and glucose ([Glc]) were assessed.
[Ad] in SCI were lower than AB throughout the study (p = 0.0002) and remained largely unchanged in both groups. [NA] increased after cold stress in AB only (p < 0.0001; GxT p = 0.006). [FFA] increased by 62% immediately after cold stress in SCI (p = 0.0028), without a difference between groups (p = 0.65). [tKB] increased by 69% at post-CS60 and 132% at post-CS120 from the start in SCI with no differences between groups (p = 0.54). [Glc] and [Ins] were reduced in SCIc only (GxT p = 0.003 and p = 0.001, respectively).
These data indicate that mild cold stress acutely elevates lipid and ketone body metabolism in persons with SCIc, despite the presence of sympathetic dysfunction.
实验研究。
比较颈脊髓损伤（SCI）患者和健全（AB）个体在轻度冷应激下的脂质代谢。
日本和歌山医科大学实验室。
9 名 SCI 男性和 11 名 AB 男性穿着水灌注服仰卧位。在 30 分钟的休息时间达到热中性后，通过水灌注服将全身冷却 15-20 分钟（CS）。在 CS 前、CS 即刻和 CS 后 60 分钟（CS60）及 120 分钟（CS120）采集血样。评估血清游离脂肪酸 ([FFA])、总酮体 ([tKB])、胰岛素 ([Ins]) 和血浆肾上腺素 ([Ad])、去甲肾上腺素 ([NA]) 和血糖 ([Glc])浓度。
整个研究过程中，SCI 中的 [Ad] 均低于 AB（p=0.0002），且两组均基本保持不变。仅 AB 组在冷应激后 [NA] 增加（p<0.0001；GxT p=0.006）。SCI 患者在冷应激后即刻 FFA 增加 62%（p=0.0028），但两组间无差异（p=0.65）。CS60 时，SCI 组 tKB 增加 69%，CS120 时增加 132%，两组间无差异（p=0.54）。仅 SCIc 患者的 [Glc] 和 [Ins] 降低（GxT p=0.003 和 p=0.001）。
这些数据表明，尽管存在交感神经功能障碍，轻度冷应激仍会急性增加 SCIc 患者的脂质和酮体代谢。
