Department of Emergency Medicine, Changhua Christian Hospital, Changhua, Taiwan.
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Sci Rep. 2022 May 4;12(1):7236. doi: 10.1038/s41598-022-11398-z.
Finding the risk factors for thromboembolic (TE) disease and preventing its development in pregnant women is important. Allergic rhinitis (AR) is a common chronic disease. We aim to find if AR is a risk factor. From 2004 to 2011, 55,057 pregnant women were recruited from a Taiwan database. They were grouped into AR and non-AR groups. The rate of TE and venous complications during pregnancy and 60 days after childbirth were compared between non-AR and the AR group. Those with AR diagnosed both before and after childbirth, meaning AR was not changed during pregnancy, the rates of TE (OR 2.64) and venous complications (OR 1.35) were higher compared to non-AR subjects. In those who underwent cesarean delivery, the rate was also higher in group 3 (OR 4.14). Those with AR before childbirth, without after, meaning AR was well controlled during pregnancy, the rate of TE was not higher than that of the non-AR subjects. Pregnant women with AR have an increased rate of TE. An increased rate of venous complications in these subjects might explain the increase in TE. If AR is well controlled during pregnancy, the rate of TE does not appear to increase.
发现血栓栓塞（TE）疾病的风险因素并预防其在孕妇中的发生非常重要。过敏性鼻炎（AR）是一种常见的慢性疾病。我们旨在确定 AR 是否是一个风险因素。2004 年至 2011 年，从台湾数据库中招募了 55057 名孕妇。他们被分为 AR 组和非 AR 组。比较了非 AR 组和 AR 组在怀孕期间和产后 60 天内 TE 和静脉并发症的发生率。那些在分娩前后均被诊断为 AR 的患者，即 AR 在怀孕期间没有改变，其 TE（OR 2.64）和静脉并发症（OR 1.35）的发生率高于非 AR 患者。在接受剖宫产的患者中，第 3 组（OR 4.14）的发生率也较高。那些在分娩前有 AR，但分娩后没有，即 AR 在怀孕期间得到很好的控制，其 TE 发生率并不高于非 AR 患者。患有 AR 的孕妇 TE 发生率增加。这些患者静脉并发症发生率的增加可能解释了 TE 发生率的增加。如果 AR 在怀孕期间得到很好的控制，TE 发生率似乎不会增加。
