2,7-二羟萘与异烟肼和吡拉西坦共晶的晶体结构。
Crystal structures of cocrystals of 2,7-dihydroxynaphthalene with isoniazid and piracetam.
机构信息
Instituto de Farmacobiología, Universidad de la Cañada, Carretera Teotitlán-San Antonio Nanahuatipán km 1.7 s/n, Teotitlán de Flores Magón, Oaxaca 68540, México.
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, México.
出版信息
Acta Crystallogr C Struct Chem. 2022 May 1;78(Pt 5):280-286. doi: 10.1107/S2053229622003734. Epub 2022 Apr 11.
Cocrystals of 2,7-dihydroxynaphthalene (DHN, or naphthalene-2,7-diol) with isoniazid (pyridine-4-carbohydrazide) (INH), denoted DHN-INH [CHO·CHNO, (I)], and piracetam [2-(2-oxopyrrolidin-1-yl)acetamide] (PIR), denoted DHN-PIR [CHO·CHNO, (II)], were obtained by the solvent-assisted grinding method and characterized by IR spectroscopy, powder X-ray diffraction and single-crystal X-ray diffraction. Cocrystal (I) crystallized in the triclinic space group P-1 and showed a 2:2 stoichiometry. DHN and INH molecules are connected by O-H...N(pyridine) and O-H...N(hydrazide) hydrogen bonds. Cocrystal (II) crystallized in the space group Pca2 with a 1:1 stoichiometry. DHN and PIR molecules are connected by O-H...O=C hydrogen bonds. The supramolecular architecture of cocrystal (I) showed interlinked supramolecular tapes; meanwhile, in cocrystal (II), interlinked supramolecular sheets were observed.
2,7-二羟基萘（DHN，或萘-2,7-二醇）与异烟肼（吡啶-4-甲酰肼）（INH）的共晶，标记为 DHN-INH [CHO·CHNO，（I）]，以及吡拉西坦[2-（2-氧代吡咯烷-1-基）乙酰胺]（PIR），标记为 DHN-PIR [CHO·CHNO，（II）]，通过溶剂辅助研磨法获得，并通过红外光谱、粉末 X 射线衍射和单晶 X 射线衍射进行了表征。共晶（I）结晶于三斜空间群 P-1，表现出 2:2 的化学计量比。DHN 和 INH 分子通过 O-H…N（吡啶）和 O-H…N（酰肼）氢键连接。共晶（II）结晶于 Pca2 空间群，具有 1:1 的化学计量比。DHN 和 PIR 分子通过 O-H…O=C 氢键连接。共晶（I）的超分子结构表现为互穿的超分子带；而在共晶（II）中，则观察到互穿的超分子片。
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