Department of Chemistry, School of Chemistry and Material Science, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of China, Hefei, 230026, P. R. China.
State Key Laboratory of Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, P. R. China.
Org Biomol Chem. 2022 May 18;20(19):3917-3921. doi: 10.1039/d2ob00623e.
A palladium-catalyzed carbonylative cyclization reaction of 2-halidebenzaldehydes with HO is described, which provides a strategy for the synthesis of diversely substituted 3,3'-oxyphthalides. Notably, the obtained 3,3'-oxyphthalide could be easily transformed into 3-aryl and alkyl phthalides with excellent efficiency using organozinc reagents under mild reaction conditions.
本文描述了钯催化的 2-卤代苯甲醛与 HO 的羰基环化反应，为合成各种取代的 3,3'-氧代邻苯二甲酸酯提供了一种策略。值得注意的是，所得的 3,3'-氧代邻苯二甲酸酯在温和的反应条件下，使用有机锌试剂可以很容易地转化为 3-芳基和烷基邻苯二甲酸酯，产率优异。
