Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
Chem Commun (Camb). 2022 May 24;58(42):6231-6234. doi: 10.1039/d2cc00292b.
Cyclic phosphatidic acids (cPAs) are bioactive compounds with therapuetic potential, but are in short supply. We describe a robust synthesis of cPAs employing an efficient cyclophosphorylation procedure and report on their hydrolytic properties - which should facilitate the study of their biological properties and as plausible proto- and synthetic-cell components.
环状磷酸脂酸（cPAs）是具有治疗潜力的生物活性化合物，但供应短缺。我们描述了一种使用高效环磷酸化程序的 cPA 稳健合成，并报告了它们的水解特性 - 这应该有助于研究它们的生物特性以及作为合理的原细胞和合成细胞成分。
