Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P. R. China.
Surgical Department of Breast and Thyroid Gland, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, 410005, P. R. China.
Chem Commun (Camb). 2022 May 24;58(42):6251-6254. doi: 10.1039/d2cc01165d.
Nanosheet carriers loaded with drugs and phototherapeutics are used for effective cancer therapy, but the process remains challenging. Here, we prepared sulfur nanosheets (S-NSs) and then loaded tirapazamine (TPZ) and indocyanine green (ICG) with a loading efficiency of 6.3% and 94%, respectively. The obtained S-NSs-TPZ-ICG exhibits near-infrared (NIR) fluorescence, high O generation and photothermal conversion capabilities, good biocompatibility, and tumor microenvironment responsiveness. and experiments reveal that S-NSs-TPZ-ICG can be selectively decomposed under acidic and HO conditions to release TPZ and ICG, and significantly inhibit tumor growth under laser irradiation without obvious toxic side effects.
载药和光疗剂的纳米片载体被用于有效的癌症治疗，但该过程仍然具有挑战性。在这里，我们制备了硫纳米片（S-NSs），然后分别以 6.3%和 94%的载药效率负载了替拉扎明（TPZ）和吲哚菁绿（ICG）。所得到的 S-NSs-TPZ-ICG 具有近红外（NIR）荧光、高 O 生成和光热转换能力、良好的生物相容性和肿瘤微环境响应性。实验表明，S-NSs-TPZ-ICG 可以在酸性和 HO 条件下选择性分解，释放 TPZ 和 ICG，并在激光照射下显著抑制肿瘤生长，没有明显的毒副作用。
