Department of Ophthalmology, Erzincan Private Neon Hospital, Erzincan, Turkey.
Department of Radiology, University of Yuksek Ihtisas, Ankara, Turkey.
Int Ophthalmol. 2022 Oct;42(10):3109-3116. doi: 10.1007/s10792-022-02310-9. Epub 2022 May 5.
This study aimed to evaluate ocular blood flow and, retinal, choroidal and retinal nerve fiber layer thickness in children with familial Mediterranean fever (FMF) with patients who had at least five attacks.
Fifty-six patients with FMF and 56 healthy subjects were enrolled in the study. Each participant's choroidal thickness (CT) and retinal thickness (RT) measurements were performed in the foveola and at horizontal nasal and temporal quadrants within 500-μm intervals up to 1.500 μm from the foveola using spectral-domain optical coherence tomography as well as the retinal nerve fiber layer thickness (RNFLT). Disc boundaries were determined manually by identifying seven points on the inner edge of the scleral ring. Following complete ophthalmological evaluation, peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistivity index (RI) values in the central retinal artery (CRA), ophthalmic artery (OA), and nasal posterior ciliary artery (NPCA) were measured using color Doppler ultrasonography (CDU) in the left eyes of the patients diagnosed with FMF and the controls. The results were subsequently compared.
No statistically significant differences were observed between the groups in terms of all RNFLT quadrant and RT measurements. All CT measurements were thinner in patients with FMF than in the controls (For Central and Temporal_1500 p = 0.01; For Temporal_500, Nasal 500 and Nasal_1000 p < 0.001; Temporal_1000 p = 0.002) except than the Nasal_1500 point. For nasal_1500 p = 0.121). The PSV and EDV values in the OA, CRA, and NPCA were significantly lower in patients with FMF compared to healthy controls (p < 0.001 for all). In contrast, the RI values of all arteries were significantly higher than in the control group (Regarding OA, CRA and NPCA RI, p = 0.003, p = 0.039, and p = 0.039, respectively).
The results of this study support the idea that chronic inflammation and frequent attacks in FMF may have an effect on decreased ocular blood flow and choroidal thinning.
本研究旨在评估有至少五次发作的家族性地中海热（FMF）患儿的眼血流以及视网膜、脉络膜和视网膜神经纤维层厚度。
本研究纳入了 56 名 FMF 患儿和 56 名健康对照者。使用频域光相干断层扫描（SD-OCT）测量每位参与者的脉络膜厚度（CT）和视网膜厚度（RT），在黄斑区以及距黄斑区 500μm 内的水平鼻侧和颞侧象限，以 500μm 的间隔测量至 1500μm 处。通过识别巩膜环内缘的 7 个点手动确定视盘边界。在进行全面的眼科评估后，使用彩色多普勒超声（CDU）测量诊断为 FMF 的患者和对照组患者左眼的中央视网膜动脉（CRA）、眼动脉（OA）和鼻睫状后动脉（NPCA）的峰值收缩速度（PSV）、舒张末期速度（EDV）和阻力指数（RI）值。随后比较结果。
在所有 RNFLT 象限和 RT 测量方面，两组之间无统计学显著差异。与对照组相比，FMF 患者的所有 CT 测量值均较薄（中央和颞侧 1500，p=0.01；颞侧 500、鼻侧 500 和鼻侧 1000，p<0.001；颞侧 1000，p=0.002，除外鼻侧 1500 点，p=0.121）。与健康对照组相比，FMF 患者的 OA、CRA 和 NPCA 的 PSV 和 EDV 值显著降低（所有均 p<0.001）。相反，所有动脉的 RI 值均明显高于对照组（OA、CRA 和 NPCA 的 RI 值，p=0.003、p=0.039 和 p=0.039）。
本研究结果支持这样一种观点，即 FMF 中的慢性炎症和频繁发作可能会影响眼血流减少和脉络膜变薄。
