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[耐氯喹恶性疟原虫引起的输入性热带疟疾的治疗]

[Treatment of imported tropical malaria caused by chloroquine-resistant strains of P. falciparum].

作者信息

Loban K M, Polozok E S, Efimov L S, Khorin A T

出版信息

Ter Arkh. 1987;59(1):69-72.

PMID:3551176
Abstract

The chloroquine-resistant strains P. falciparum are widely spread in the countries of South-East Asia, Latin America. Since the middle of the 70s the strains also occurred in Eastern Africa. The given paper is concerned with 4 patients suffering from imported chloroquine-resistant tropical malaria. Of these, 3 patients come from Africa, and one from Vietnam. In the latter patient, the disease ran a grave course and was attended by coma, acute renal insufficiency, hepatitis, and hemolytic anemia. The patient was registered as having grade III resistance of P. falciparum to chloroquine. The schedules of the disease treatment including quinine with fansidar, metakelphin (or with sulphalene and chloridine), mafloquine or tetracycline are presented.

摘要

抗氯喹恶性疟原虫菌株在东南亚、拉丁美洲国家广泛传播。自70年代中期起,这些菌株也出现在东非。本文涉及4例输入性抗氯喹热带疟疾患者。其中3例患者来自非洲,1例来自越南。后一名患者病情严重,出现昏迷、急性肾功能不全、肝炎和溶血性贫血。该患者被登记为恶性疟原虫对氯喹有III级耐药。文中介绍了包括奎宁与Fansidar、甲喹酮(或与磺胺林和氯胍)、甲氟喹或四环素在内的疾病治疗方案。

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