Niederwieser D, Aulitzky W, Frommhold H, Schönitzer D, Url M, Allerberger F, Wiegele J, Gratwohl A, Braunsteiner H, Huber C
Wien Klin Wochenschr. 1987 Jan 23;99(2):49-53.
Between October 1983 and October 1985, 12 allogeneic bone marrow transplantations from HLA-identical siblings were performed for treatment of malignant disease (11 haemopoietic malignancies) or severe aplastic anaemia (1 case). All patients showed prompt and complete engraftment of donor cells on average around day 17 after transplantation. 10 patients are alive and well 50-760 days after transplantation, without any signs of recurrence and partly without immunosuppressive therapy. Two patients died, one due to relapse of the leukaemia, and one as a result of CMV interstitial pneumonia. Graft versus host disease was seen in 6 of the 12 patients. Additional immunosuppressive therapy was necessary in 4 of them. The incidence of idiopathic interstitial pneumonia in our group of patients was low (two cases). Also tested was an experimental protocol for the treatment of chemotherapy-resistant metastatic solid tumours. After removal of all clinically detectable tumour tissue by maximal surgical therapy in 5 patients, residual systemic metastases were treated by means of total body irradiation and high-dose cyclophosphamide, followed by autologous bone marrow transplantation with curative intention. Relapse occurred in 4 patients between day 100 and 720 after BMT bone marrow transplantation. Only one patient remains without sign of relapse.
1983年10月至1985年10月期间，对12例患有恶性疾病（11例造血系统恶性肿瘤）或严重再生障碍性贫血（1例）的患者进行了来自 HLA 相同同胞的异基因骨髓移植。所有患者在移植后平均约第17天均迅速且完全植入了供体细胞。10例患者在移植后50 - 760天存活且状况良好，无任何复发迹象，部分患者无需免疫抑制治疗。2例患者死亡，1例死于白血病复发，1例死于巨细胞病毒间质性肺炎。12例患者中有6例出现移植物抗宿主病，其中4例需要额外的免疫抑制治疗。我们这组患者中特发性间质性肺炎的发生率较低（2例）。还测试了一种治疗化疗耐药转移性实体瘤的实验方案。5例患者通过最大程度的手术治疗切除所有临床可检测到的肿瘤组织后，残余的全身转移灶采用全身照射和大剂量环磷酰胺治疗，随后进行有治愈意图的自体骨髓移植。4例患者在骨髓移植后第100天至720天之间复发。只有1例患者无复发迹象。
