Bohle A, Mackensen-Haen S, von Gise H
Zentralbl Allg Pathol. 1986;132(5-6):351-63.
Results are presented for morphologic investigations on the correlation between structural and functional alterations in various inflammatory and non-inflammatory glomerular and extraglomerular renal diseases. The role of the glomeruli in the excretion of substances excreted exclusively by the urinary tract is dependent, to a degree not previously appreciated, on the condition of the postglomerular vasculature as well as on the functional status of the tubular epithelium. All processes which result in damage to the post-glomerular vasculature negatively influence glomerular excretory function by limiting the flow of blood out of the glomeruli and reducing glomerular perfusion. It is further assumed that all processes which negatively influence tubular reabsorption will also be detrimental to glomerular function as a result of increased pressure in the proximal renal tubule as well as via the Thurau mechanism. Finally it is suggested that the kidney's concentrating ability is partially dependent on tubular interstitial factors: with increasing width of the renal cortical interstitium and increasing atrophy of the renal tubule (as measured by the proximal tubules) the kidney's concentrating ability steadily diminishes.
本文展示了关于各种炎性和非炎性肾小球及肾小球外肾脏疾病中结构与功能改变之间相关性的形态学研究结果。肾小球在仅通过尿路排泄的物质排泄中所起的作用，在一定程度上依赖于肾小球后血管系统的状况以及肾小管上皮的功能状态，而这种依赖程度是此前未被认识到的。所有导致肾小球后血管系统受损的过程，都会通过限制血液流出肾小球和减少肾小球灌注，对肾小球排泄功能产生负面影响。进一步推测，所有对肾小管重吸收产生负面影响的过程，也会由于近端肾小管压力增加以及通过图劳机制而损害肾小球功能。最后表明，肾脏的浓缩能力部分依赖于肾小管间质因素：随着肾皮质间质宽度增加以及肾小管（以近端小管测量）萎缩加剧，肾脏的浓缩能力会持续下降。
