Syposs T, Csiba A, Novák J, Gráber H, Firr M
Zentralbl Chir. 1986;111(24):1519-25.
Antibiotic serum levels were recorded from 100 patients with burns. Antibiotic doses to ensure effective serum levels were found to be in excess of maximum values quoted as necessary by manufacturers, provided that serum creatinine was normal. These findings were in agreement with literature data. This was the first instance to check on serum levels, following oral administration of antibiotics. Differences between individual patients may be considerable, probably due to variable renal blood supply and other factors. Individual dosage with control of serum levels is, therefore, recommended. Specific dosage recommendation for patients with burns would be desirable for hospital practice.
记录了100名烧伤患者的抗生素血清水平。结果发现,在血清肌酐正常的情况下,为确保有效血清水平所需的抗生素剂量超过了制造商引用的最大值。这些发现与文献数据一致。这是首次在口服抗生素后检查血清水平。个体患者之间的差异可能相当大,这可能是由于肾血流量不同和其他因素所致。因此,建议根据个体情况给药并控制血清水平。对于医院实践来说,给出针对烧伤患者的具体给药建议是很有必要的。