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植物生物碱外消旋微鞘蕊花碱A的全合成：具有三环喹啉-锯齿烷骨架的天然产物的首例。

Total synthesis of the plant alkaloid racemic microthecaline A: first example of a natural product bearing a tricyclic quinoline-serrulatane scaffold.

作者信息

Penjarla Thirupathi Reddy, Kundarapu Maheshwar, Baquer Syed Mohd, Bhattacharya Anupam

机构信息

Department of Chemistry, Birla Institute of Technology and Science-Pilani (Hyderabad Campus) Hyderabad-500078 India

Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd. Survey No. 125 (Part) & 126, IDA Mallapur Hyderabad 500076 India.

出版信息

RSC Adv. 2019 Jul 26;9(40):23289-23294. doi: 10.1039/c9ra04675e. eCollection 2019 Jul 23.

DOI:10.1039/c9ra04675e
PMID:35514523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9067311/
Abstract

The first total synthesis of racemic microthecaline A, a quinoline serrulatane alkaloid, isolated from the Australian desert plant is described. The natural product was synthesized in ten steps, starting from ethyl 4-bromo-6-methoxy-8-methylquinoline-3-carboxylate in 8% overall yield.

摘要

本文描述了从澳大利亚沙漠植物中分离得到的喹啉锯齿烷生物碱外消旋微鞘碱A的首次全合成。该天然产物以4-溴-6-甲氧基-8-甲基喹啉-3-羧酸乙酯为起始原料，经十步反应合成，总收率为8%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4705/9067311/b487ecc79e9e/c9ra04675e-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4705/9067311/6742f2396664/c9ra04675e-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4705/9067311/11205cbbd529/c9ra04675e-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4705/9067311/f29895c02466/c9ra04675e-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4705/9067311/b487ecc79e9e/c9ra04675e-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4705/9067311/6742f2396664/c9ra04675e-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4705/9067311/11205cbbd529/c9ra04675e-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4705/9067311/f29895c02466/c9ra04675e-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4705/9067311/b487ecc79e9e/c9ra04675e-s4.jpg

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