从带有噻唑烷和氨氧基乙酰基的肽进行一锅法肟连接反应。
One-pot oxime ligation from peptides bearing thiazolidine and aminooxyacetyl groups.
作者信息
Duflocq Stéphane, Zhou Jingjing, Huguenot Florent, Vidal Michel, Liu Wang-Qing
机构信息
Université de Paris, CiTCoM, 8038 CNRS, U 1268 INSERM F-75006 Paris France
Service Biologie du médicament, toxicologie, AP-HP, Hôpital Cochin F-75014 Paris France.
出版信息
RSC Adv. 2020 May 6;10(30):17681-17685. doi: 10.1039/d0ra03235b. eCollection 2020 May 5.
One-pot oxime ligation under mild conditions using Pd(ii) as a shared catalyst from an aldehyde precursor (Thz) and a protected aminooxyacetyl group (Proc-Aoa) is reported. Two complementary metal-free protocols using unmasked Aoa-peptide are also described. Acetoxime-peptide can proceed to the desired oxime through an additional transoximation step.
报道了在温和条件下使用Pd(ii)作为醛前体(Thz)和受保护的氨氧基乙酰基(Proc-Aoa)的共享催化剂进行一锅法肟连接反应。还描述了两种使用未保护的Aoa-肽的无金属互补方案。乙酰肟-肽可通过额外的肟交换步骤生成所需的肟。
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