新型二聚氮杂三过氧化物的合成与抗癌活性
Synthesis and anticancer activity novel dimeric azatriperoxides.
作者信息
Makhmudiyarova Nataliya N, Ishmukhametova Irina R, Dzhemileva Lilya U, Tyumkina Tatyana V, D'yakonov Vladimir A, Ibragimov Askhat G, Dzhemilev Usein M
机构信息
Institute of Petrochemistry and Catalysis, Russian Academy of Sciences 141 Prospekt Oktyabrya 450075 Ufa Russian Federation
出版信息
RSC Adv. 2019 Jun 17;9(33):18923-18929. doi: 10.1039/c9ra02950h. eCollection 2019 Jun 14.
An efficient method was developed for the synthesis of tetra(spirocycloalkane)-substituted α,ω-di(1,2,4,5,7,8-hexaoxa-10-azacycloundecan-10-yl)alkanes by a ring transformation reaction of 3,6-di(spirocycloalkane)-substituted 1,2,4,5,7,8,10-heptaoxacycloundecanes with α,ω-alkanediamines (1,4-butane-, 1,5-pentane-, 1,7-heptane-, 1,8-octane- and 1,10-decanediamines) catalyzed by Sm(NO)/γ-AlO. Using flow cytometry, it was shown for the first time that synthesized dimeric azatriperoxides are efficient apoptosis inducers with Jurkat, K562, U937, and Hek296.
通过Sm(NO)/γ-Al₂O₃催化的3,6-二(螺环烷烃)-取代的1,2,4,5,7,8,10-七氧杂环十一烷与α,ω-链烷二胺（1,4-丁二胺、1,5-戊二胺、1,7-庚二胺、1,8-辛二胺和1,10-癸二胺）的环转化反应，开发了一种高效合成四(螺环烷烃)-取代的α,ω-二(1,2,4,5,7,8-六氧杂-10-氮杂环十一烷-10-基)烷烃的方法。使用流式细胞术首次表明，合成的二聚氮杂三过氧化物是Jurkat、K562、U937和Hek296细胞有效的凋亡诱导剂。
Zotero 插件