1,5-二氮杂环庚烷-2-酮的简便合成：连接的磺酰胺环化生成环丙烯。
Facile assembly of 1,5-diazocan-2-ones cyclization of tethered sulfonamides to cyclopropenes.
作者信息
Matheny Jonathon P, Yamanushkin Pavel M, Petillo Peter A, Rubin Michael
机构信息
Department of Chemistry, University of Kansas 1567 Irving Hill Road Lawrence KS 66045-7582 USA
Design-Zyme LLC 4950 Research Park Way Lawrence KS 66047 USA.
出版信息
RSC Adv. 2020 Dec 15;10(72):44183-44190. doi: 10.1039/d0ra09014j. eCollection 2020 Dec 9.
Abstract
The sulfonamide moiety was evaluated as an activating and stabilizing functional group in the metal-templated strain release-driven intramolecular nucleophilic addition of amines to cyclopropenes to generate 1,5-diazocan-2-ones.
摘要
在金属模板化的应变释放驱动的胺与环丙烯的分子内亲核加成反应中，磺胺部分被评估为一种活化和稳定的官能团，用于生成1,5-二氮杂环庚-2-酮。
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