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新型耐盐抗菌肽RR12的结构-功能关系表征

Characterization of the structure-function relationship of a novel salt-resistant antimicrobial peptide, RR12.

作者信息

Wu Ping-Sheng, Lai Shu-Jung, Fung Kit-Man, Tseng Tien-Sheng

机构信息

Division of Infectious Diseases, Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation New Taipei Taiwan.

Institute of Biological Chemistry, Academia Sinica Taipei 115 Taiwan.

出版信息

RSC Adv. 2020 Jun 22;10(40):23624-23631. doi: 10.1039/d0ra04299d. eCollection 2020 Jun 19.

DOI:10.1039/d0ra04299d
PMID:35517355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9054785/
Abstract

Antimicrobial peptides (AMPs) are potential candidates in designing new anti-infective agents. However, many AMPs show poor bactericidal activities in physical salt and serum solutions. Here, we disclosed the structure-function relationships of a novel salt-resistant antimicrobial peptide, RR12, which could further explain its mode of action and show its applicability in developing new antibacterial agents.

摘要

抗菌肽是设计新型抗感染药物的潜在候选物。然而，许多抗菌肽在生理盐溶液和血清中表现出较差的杀菌活性。在此，我们揭示了一种新型耐盐抗菌肽RR12的结构-功能关系，这可以进一步解释其作用模式，并展示其在开发新型抗菌药物中的适用性。

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Structural and Functional Enrichment Analyses for Antimicrobial Peptides.

本文引用的文献

1
Salt-resistant short antimicrobial peptides.耐盐性短抗菌肽
Biopolymers. 2016 May;106(3):345-56. doi: 10.1002/bip.22819.
2
APD3: the antimicrobial peptide database as a tool for research and education.APD3：作为研究与教育工具的抗菌肽数据库
Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
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Functions of Antimicrobial Peptides in Gut Homeostasis.抗菌肽在肠道稳态中的作用。
抗菌肽的结构和功能富集分析。
Int J Mol Sci. 2020 Nov 20;21(22):8783. doi: 10.3390/ijms21228783.
Curr Protein Pept Sci. 2015;16(7):582-91. doi: 10.2174/1389203716666150630135847.
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The antibiotic resistance crisis: part 2: management strategies and new agents.抗生素耐药性危机：第2部分：管理策略与新药物
P T. 2015 May;40(5):344-52.
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The antibiotic resistance crisis: part 1: causes and threats.抗生素耐药性危机：第一部分：成因与威胁。
P T. 2015 Apr;40(4):277-83.
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Antimicrobial Peptides (AMPs) with Dual Mechanisms: Membrane Disruption and Apoptosis.具有双重作用机制的抗菌肽：膜破坏与细胞凋亡
J Microbiol Biotechnol. 2015 Jun;25(6):759-64. doi: 10.4014/jmb.1411.11058.
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Sonorensin: an antimicrobial peptide, belonging to the heterocycloanthracin subfamily of bacteriocins, from a new marine isolate, Bacillus sonorensis MT93.索诺菌素：一种抗菌肽，属于细菌素的杂环蒽素亚家族，源自新的海洋分离株索诺芽孢杆菌MT93。
Appl Environ Microbiol. 2014 May;80(10):2981-90. doi: 10.1128/AEM.04259-13. Epub 2014 Mar 7.
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Antimicrobial peptides.抗菌肽。
Pharmaceuticals (Basel). 2013 Nov 28;6(12):1543-75. doi: 10.3390/ph6121543.
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Structure, antimicrobial activities and mode of interaction with membranes of novel [corrected] phylloseptins from the painted-belly leaf frog, Phyllomedusa sauvagii.新型斑腿泛树蛙（Phyllomedusa sauvagii）叶褶蛙素的结构、抗菌活性及其与膜相互作用的模式。
PLoS One. 2013 Aug 13;8(8):e70782. doi: 10.1371/journal.pone.0070782. eCollection 2013.
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De novo generation of short antimicrobial peptides with enhanced stability and cell specificity.具有增强稳定性和细胞特异性的新型短抗菌肽的生成。
J Antimicrob Chemother. 2014 Jan;69(1):121-32. doi: 10.1093/jac/dkt322. Epub 2013 Aug 14.