Cai Hanxu, Yao Ya, Xu Yang, Wang Qing, Zou Wen, Liang Jie, Sun Yong, Zhou Changchun, Fan Yujiang, Zhang Xingdong
National Engineering Research Center for Biomaterials, Sichuan University 29 Wangjiang Road Chengdu 610064 P. R. China.
Sichuan Testing Center for Biomaterials and Medical Devices, Sichuan University 29 Wangjiang Road Chengdu 610064 China
RSC Adv. 2019 Jan 29;9(7):3740-3748. doi: 10.1039/c8ra09171d. eCollection 2019 Jan 25.
Osteochondral defects occur in the superficial cartilage region, intermediate calcified cartilage, and subchondral bone. Due to the limited regenerative capacity and complex zonal structure, it is critically difficult to develop strategies for osteochondral defect repair that could meet clinical requirements. In this study, type I collagen (Col I) and BCP ceramics were used to fabricate a new bi-layer scaffold for regeneration in osteochondral defects. The studies showed that the bi-layer scaffold provided special functions for cell migration, proliferation and secretion due to the layered scaffold structure. The results demonstrated that the bi-layered scaffold could effectively promote the regeneration of both the cartilage and the subchondral bone, and the newly formed cartilage layer, with a similar structure and thickness to the natural cartilaginous layer, could seamlessly integrate with the surrounding natural cartilage and regenerate an interface layer to mimic the native osteochondral structure.
骨软骨缺损发生在表层软骨区域、中间钙化软骨和软骨下骨。由于再生能力有限且区域结构复杂，开发能够满足临床需求的骨软骨缺损修复策略极具挑战性。在本研究中，使用I型胶原蛋白（Col I）和BCP陶瓷制备了一种用于骨软骨缺损再生的新型双层支架。研究表明，由于分层支架结构，该双层支架为细胞迁移、增殖和分泌提供了特殊功能。结果表明，双层支架能够有效促进软骨和软骨下骨的再生，新形成的软骨层结构和厚度与天然软骨层相似，能够与周围天然软骨无缝整合并再生界面层，以模拟天然骨软骨结构。
