[Experimental Candida infection in mice due to intracerebral contamination].

Candida infection caused by intracerebral administration of collection and clinical strains of C. albicans was studied on 1000 albino mice. The infecting doses ranged from 5 X 10(6) to 200 X 10(6) cells. Developing infection might be characterized as Candida encephalomeningitis complicated by generalized candidiasis. Acute purulent inflammations in the tissues of the brain, kidneys and myocardium developing at early periods after the infection were replaced by granulomatous reaction and fibroplastic processes. Generalization of the infection was confirmed by C. albicans isolation from blood and internal organs. Development of multiple microabscesses in the brain tissue and early severe affections in the kidneys and myocardium were a pathomorphological characteristics of the infectious process due to administration of a clinical virulent strain of C. albicans to the brain. Intracerebral administration of various C. albicans strains to mice provided their differentiation by the virulent properties.