通过1-磺酰基-4-(2-氨基甲基苯基)-1,2,3-三唑的分子内环化反应，简便地无金属一锅法合成3-氨基异喹啉。
A facile metal-free one-pot synthesis of 3-aminoisoquinolines by intramolecular transannulation of 1-sulfonyl-4-(2-aminomethylphenyl)-1,2,3-triazoles.
作者信息
Shang Hai, Li Ling-Yu, Tian Yu, Jia Hong-Mei, Zou Zhong-Mei
机构信息
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing 100193 P. R. China
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing 100050 P. R. China.
出版信息
RSC Adv. 2020 Oct 28;10(64):39067-39071. doi: 10.1039/d0ra06563c. eCollection 2020 Oct 21.
A metal-free one-pot intramolecular transannulation of 1-sulfonyl-4-(2-aminomethylphenyl)-1,2,3-triazoles has been developed, which enables the facile synthesis of the various 3-aminoisoquinolines as well as relevant scaffolds from readily available starting materials.
已开发出一种1-磺酰基-4-(2-氨甲基苯基)-1,2,3-三唑的无金属一锅法分子内环化反应，该反应能够从容易获得的起始原料轻松合成各种3-氨基异喹啉以及相关骨架。
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