Jin Lifang, Wang Cuizhu, Liu Jinping, Li Pingya, Li Jing, Cui Xiaoli, Wang Yi
School of Pharmaceutical Sciences, Jilin University Fujin Road 126 Changchun 130021 China
Department of Hematology and Oncology, The Second Hospital of Jilin University Changchun 130041 China.
RSC Adv. 2020 Jul 9;10(43):25999-26005. doi: 10.1039/d0ra01683g. eCollection 2020 Jul 3.
Pseudo-ginsengenin DQ (PDQ) is the product of the oxidative cyclization of protopanaxadiol. PDQ exhibits various bioactivities, including reversal of multidrug resistance in cancer, renal protective effects against acute nephrotoxicity and attenuating myocardial ischemia injury induced by isoproterenol or ligation of coronary arterials, but its effect on arrhythmias has not been clear until now. Because of the complicated effects of ginseng on the cardiovascular system, it is necessary to investigate whether PDQ affects arrhythmias, which are always concomitant with other cardiac diseases. Aconitine was used to induce arrhythmia . To understand its electrophysiological fundamental, whole-cell patch-clamp was used to record the L-type calcium current ( ) and potassium currents ( and ) in the ventricular myocytes in rats. Oral administration of PDQ exerted obvious antiarrhythmic effects, as indicated by the decreased incidence rate, lower number of occurrences, and shorter duration time of ventricular tachycardia and ventricular tachycardia, decreased mortality rate and increased survival time. and were inhibited by PDQ treatment while was not affected. To conclude, PDQ may have an anti-arrhythmia effect through inhibiting and .
伪人参二醇DQ（PDQ）是原人参二醇氧化环化的产物。PDQ具有多种生物活性，包括逆转癌症中的多药耐药性、对急性肾毒性的肾脏保护作用以及减轻异丙肾上腺素或冠状动脉结扎诱导的心肌缺血损伤，但迄今为止其对心律失常的影响尚不清楚。由于人参对心血管系统的影响复杂，因此有必要研究PDQ是否会影响心律失常，而心律失常往往与其他心脏疾病相伴。乌头碱被用于诱导心律失常。为了解其电生理基础，采用全细胞膜片钳记录大鼠心室肌细胞中的L型钙电流（ ）和钾电流（ 和 ）。口服PDQ具有明显的抗心律失常作用，表现为室性心动过速和室性心动过速的发生率降低、发生次数减少、持续时间缩短、死亡率降低以及存活时间延长。PDQ处理可抑制 和 ，而 不受影响。总之，PDQ可能通过抑制 和 发挥抗心律失常作用。
