School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China.
Molecules. 2020 Nov 27;25(23):5562. doi: 10.3390/molecules25235562.
Ginseng is one of the most widely consumed herbs in the world and plays an important role in counteracting fatigue and alleviating stress. The main active substances of ginseng are its ginsenosides. Ocotillol-type triterpenoid is a remarkably effective ginsenoside from Vietnamese ginseng that has received attention because of its potential antibacterial, anticancer and anti-inflammatory properties, among others. The semisynthesis, modification and biological activities of ocotillol-type compounds have been extensively studied in recent years. The aim of this review is to summarize semisynthesis, modification and pharmacological activities of ocotillol-type compounds. The structure-activity relationship studies of these compounds were reported. This summary should prove useful information for drug exploration of ocotillol-type derivatives.
人参是世界上应用最广泛的草药之一，在抗疲劳和缓解压力方面发挥着重要作用。人参的主要活性物质是其人参皂苷。奥克梯醇型三萜是越南人参中一种非常有效的人参皂苷，由于其具有潜在的抗菌、抗癌和抗炎等特性而受到关注。近年来，奥克梯醇型化合物的半合成、修饰和生物活性得到了广泛的研究。本综述的目的是总结奥克梯醇型化合物的半合成、修饰和药理学活性。报道了这些化合物的构效关系研究。这一总结应为奥克梯醇型衍生物的药物探索提供有用的信息。
