Ravyn Dana, Goodwin Beth, Lowney Rob, Chapman Arlene
CMEology, West Hartford, CT.
Section of Nephrology, Department of Medicine, Institute for Translational Medicine, University of Chicago, Chicago, IL.
Kidney Med. 2022 Apr 1;4(5):100459. doi: 10.1016/j.xkme.2022.100459. eCollection 2022 May.
RATIONALE & OBJECTIVE: The translation of clinical research to practice has been the subject of intense scrutiny in the efforts to identify ways to improve the uptake of findings that can enhance patient care.
This study evaluated the experience of nephrology health care providers who manage patients with autosomal dominant polycystic kidney disease (ADPKD) to identify promoters and barriers to the translation of research results into clinical practice. We used inductive thematic analysis to evaluate the experience, attitudes, and beliefs of physicians in the evaluation and translation of research findings into clinical practice for the care of patients with ADPKD.
SETTING & PARTICIPANTS: Participants in a continuing education activity on ADPKD volunteered for semistructured interviews exploring their experience translating new knowledge into care for patients with ADPKD. An independent institutional review board (Solutions IRB) found the study to be exempt as an educational survey.
Transcripts were coded and excerpted, and emergent themes and relationships were identified through an analysis performed using Dedoose software. Particular attention was paid to characterizing the facilitators and barriers to research translation at different levels of the health care environment.
Textual interpretation of data from 13 interviews showed that while well-established barriers to research translation are prevalent among health care providers managing patients with ADPKD, these clinicians also face unique challenges. Principal among these is the burden of interpreting the clinical research literature given the lack of official guidelines.
This study did not explore the translation of all levels of research, such as basic science and animal studies, and it was limited to the translation of knowledge from clinical studies. The number of participants was limited but was found to be sufficient for saturation.
We identified factors that may either enhance or impede research translation for nephrology health care providers. These observations may help in the design of continuing education interventions to promote innovation.
临床研究成果转化为实际应用一直是备受严格审查的主题，旨在探寻提高可改善患者护理的研究结果应用率的方法。
本研究评估了管理常染色体显性多囊肾病（ADPKD）患者的肾脏病医疗服务提供者的经验，以确定将研究结果转化为临床实践的促进因素和障碍。我们采用归纳主题分析法来评估医生在将研究结果评估并转化为ADPKD患者护理临床实践中的经验、态度和信念。
一项关于ADPKD的继续教育活动的参与者自愿接受半结构化访谈，探讨他们将新知识转化为ADPKD患者护理的经验。一个独立的机构审查委员会（Solutions IRB）认定该研究作为一项教育调查可获豁免。
对访谈记录进行编码和摘录，并通过使用Dedoose软件进行的分析来确定新出现的主题和关系。特别关注描述医疗环境不同层面上研究转化的促进因素和障碍。
对13次访谈数据的文本解读表明，虽然在管理ADPKD患者的医疗服务提供者中，研究转化的既定障碍普遍存在，但这些临床医生也面临独特的挑战。其中最主要的是由于缺乏官方指南而导致的解读临床研究文献的负担。
本研究未探讨所有层面研究的转化，如基础科学和动物研究，且仅限于临床研究知识的转化。参与者数量有限，但已发现足以达到饱和状态。
我们确定了可能增强或阻碍肾脏病医疗服务提供者进行研究转化的因素。这些观察结果可能有助于设计促进创新的继续教育干预措施。
