Akolkar Satish V, Nagargoje Amol A, Krishna Vagolu S, Sriram Dharmarajan, Sangshetti Jaiprakash N, Damale Manoj, Shingate Bapurao B
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University Aurangabad 431 004 India
Department of Pharmacy, Birla Institute of Technology & Science-Hyderabad Campus Jawahar Nagar Hyderabad 500 078 India.
RSC Adv. 2019 Jul 18;9(38):22080-22091. doi: 10.1039/c9ra03425k. eCollection 2019 Jul 11.
A facile, highly efficient, and greener method for the synthesis of new 1,4-disubstituted-1,2,3-triazoles was conducted using [EtNH][OAc] as a medium by the implementation of ultrasound irradiation click chemistry, affording excellent yields. The present synthetic method exhibited numerous advantages such as mild reaction conditions, excellent product yields, minimal chemical waste, operational simplicity, shorter reaction time, and a wide range of substrate scope. The synthesized compounds were further evaluated for antifungal activity against five fungal strains, and some of the compounds displayed equivalent or greater potency than the standard drug. A molecular docking study against the modelled three-dimensional structure of cytochrome P450 lanosterol 14α-demethylase was also performed to understand the binding affinity and binding interactions of the enzyme. Furthermore, the synthesized compounds were evaluated for DPPH radical scavenging activity and antitubercular activity against H37Rv strain.
通过超声辐射点击化学，以[EtNH][OAc]为介质，开发了一种简便、高效且更环保的合成新型1,4 - 二取代 - 1,2,3 - 三唑的方法，产率优异。本合成方法具有诸多优点，如反应条件温和、产品收率高、化学废物最少、操作简便、反应时间短以及底物范围广。对合成的化合物针对五种真菌菌株进行了抗真菌活性评估，部分化合物显示出与标准药物相当或更高的效力。还针对细胞色素P450羊毛甾醇14α - 脱甲基酶的模拟三维结构进行了分子对接研究，以了解该酶的结合亲和力和结合相互作用。此外，对合成的化合物进行了DPPH自由基清除活性评估以及针对H37Rv菌株的抗结核活性评估。
