通过低分子量季铵化合物与葫芦[7]脲的非共价复合物的基质辅助激光解吸电离质谱法进行超分子辅助成像。
Supermolecule-assisted imaging of low-molecular-weight quaternary-ammonium compounds by MALDI-MS of their non-covalent complexes with cucurbit[7]uril.
作者信息
Chen Di, Han Jun, Yang Juncong, Schibli David, Zhang Zhenzhong, Borchers Christoph H
机构信息
University of Victoria - Genome British Columbia Proteomics Centre Victoria BC V8Z 7X8 Canada
School of Pharmaceutical Sciences, Zhengzhou University Zhengzhou 450001 China.
出版信息
RSC Adv. 2020 Sep 15;10(56):34261-34265. doi: 10.1039/d0ra04604c. eCollection 2020 Sep 10.
Abstract
Cucurbit[7]uril was used to form non-covalent complexes with low-molecular-weight quaternary-ammonium compounds for their indirect analysis by MALDI-MS. By shifting the ion signals to a higher and interference-free mass region, the distributions of neurine, choline, and phosphocholine in rat brain were visualized by MALDI imaging with high selectivity and good sensitivity.
摘要
葫芦[7]脲用于与低分子量季铵化合物形成非共价复合物，以便通过基质辅助激光解吸电离质谱（MALDI-MS）对其进行间接分析。通过将离子信号转移到更高且无干扰的质量区域，利用MALDI成像以高选择性和良好的灵敏度可视化了大鼠脑中神经碱、胆碱和磷酸胆碱的分布。
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