Miao Yanming, Yang Wenli, Lv Jinzhi
Shanxi Normal University Linfen 041004 PR China
RSC Adv. 2020 Jul 30;10(47):28205-28212. doi: 10.1039/d0ra03791e. eCollection 2020 Jul 27.
Traditional chemical and biological sensors developed through aggregation-induced emission (AIE) are mainly based on "Turning on" pattern of fluorescence enhancement, which often has poor selectivity and can be easily interfered with by other substances. On this basis, an AIE-based tetraphenyl ethylene (TPE) derivative (TPE-COOH) was prepared in this study and aggregated by adding Al, so as to form the TPE-COOH/Al polymer. TPE-COOH fluorescence was enhanced through AIE principle, thus realizing the "Turning on" state. F could bind to Al after the addition of F ions which would result in the decomposition of TPE-COOH/Al aggregate, dissolved state of TPE-COOH and gradual reduction of fluorescence intensity of the system, thus realizing "Turning off" state. Moreover, F ions in biological fluid were analyzed and detected through such AIE-based "Turning on-off" pattern. The linear range of this method for F detection was 3-12 μM and the detection limit was 0.9 μM.
通过聚集诱导发光（AIE）开发的传统化学和生物传感器主要基于荧光增强的“开启”模式，这种模式通常选择性较差，容易受到其他物质的干扰。在此基础上，本研究制备了一种基于AIE的四苯基乙烯（TPE）衍生物（TPE-COOH），并通过添加铝使其聚集，从而形成TPE-COOH/Al聚合物。TPE-COOH的荧光通过AIE原理增强，从而实现“开启”状态。加入氟离子后，F可以与铝结合，导致TPE-COOH/Al聚集体分解，TPE-COOH处于溶解状态，体系荧光强度逐渐降低，从而实现“关闭”状态。此外，通过这种基于AIE的“开启-关闭”模式对生物流体中的氟离子进行了分析检测。该方法检测F的线性范围为3-12μM，检测限为0.9μM。
