胰岛素可导致人红细胞血影中的胰岛素受体内化。
Insulin causes insulin-receptor internalization in human erythrocyte ghosts.
作者信息
Kelleher R S, Murray E F, Peterson S W
出版信息
Biochem J. 1987 Jan 1;241(1):93-7. doi: 10.1042/bj2410093.
Abstract
The effect of incubation with insulin on insulin-receptor internalization by erythrocyte ghosts was investigated. The number of surface insulin receptors decreased by 30-40% after incubation of ghosts with insulin. Total insulin-receptor binding to solubilized ghosts was the same in insulin-incubated and control ghosts, whereas insulin binding to an internal vesicular fraction was substantially increased in insulin-incubated ghosts. Our findings suggest that erythrocyte-ghost insulin receptors are internalized to a vesicular compartment in response to incubation with insulin.
摘要
研究了胰岛素孵育对红细胞血影胰岛素受体内化的影响。将血影与胰岛素孵育后，表面胰岛素受体数量减少了30%-40%。胰岛素孵育的血影和对照血影中，与可溶性血影结合的总胰岛素受体相同，而胰岛素孵育的血影中，与内部囊泡部分的胰岛素结合显著增加。我们的研究结果表明，红细胞血影胰岛素受体在与胰岛素孵育后会内化到囊泡区室。
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