1-苯基-（苯并噻唑-2-基）甲亚胺衍生物作为中东呼吸综合征冠状病毒抑制剂
1-Phenyl--(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors.
作者信息
Hu Min-Qi, Li Heng, Lin Ying, Zhang Ying, Tang Jie, Zuo Jian-Ping, Yu Li-Fang, Tong Xian-Kun, Tang Wei, Yang Fan
机构信息
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University Shanghai 200062 China
Shanghai Institute of Materia Medica, Chinese Academy of Sciences Shanghai 201203 China
出版信息
RSC Adv. 2020 Dec 7;10(71):43299-43311. doi: 10.1039/d0ra08442e. eCollection 2020 Nov 27.
Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl--(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 μM is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.
中东呼吸综合征冠状病毒（MERS-CoV）对人类健康构成严重威胁，目前尚无有效的特异性疗法来治疗该病毒。本文描述了一系列对MERS-CoV具有抑制活性的1-苯基-（苯并噻唑-2-基）甲亚胺衍生物。抑制浓度值为0.09μM的化合物4f是一种有前景的抑制剂，值得进一步评估，以开发潜在的抗MERS-CoV药物。
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