一种合成2-烷氧基吲哚-3-酮的简便方法及其在合成苄基马替莫酮中的应用。
A facile approach to 2-alkoxyindolin-3-one and its application to the synthesis of -benzyl matemone.
作者信息
Shimizu Makoto, Imazato Hayao, Mizota Isao, Zhu Yusong
机构信息
School of Energy Science and Engineering, Nanjing Tech University Nanjing 211816 Jiangsu Province China.
Department of Chemistry for Materials, Graduate School of Engineering, Mie University Tsu Mie 514-8507 Japan
出版信息
RSC Adv. 2019 Jun 3;9(30):17341-17346. doi: 10.1039/c9ra02204j. eCollection 2019 May 29.
Abstract
2-Alkoxycarbonylindolin-3-one is synthesized from a methoxyglycine derivative a 1,2-aza-Brook rearrangement followed by cyclization with bis(trimethylsilyl)aluminum chloride. A short-step synthesis of -benzyl matemone is successfully carried out using the present indolin-3-one synthesis.
摘要
2-烷氧羰基吲哚啉-3-酮由甲氧基甘氨酸衍生物经1,2-氮杂-Brook重排，然后与双(三甲基硅基)氯化铝环化合成。利用本吲哚啉-3-酮合成方法成功实现了β-苄基马特莫酮的短步骤合成。
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