Department of Chemistry for Materials, Graduate School of Engineering, Mie University , Tsu, Mie 514-8507, Japan.
Org Lett. 2014 Apr 18;16(8):2276-9. doi: 10.1021/ol5007983. Epub 2014 Apr 10.
This report describes a highly regioselective tandem N-alkylation/vinylogous aldol reaction of β,γ-alkenyl α-iminoesters. The sulfur group improves the regioselectivity of the directed vinylogous aldol reaction, providing a new synthetic method of 3-amino-2-pyrones.
本报告描述了β,γ-烯基α-亚氨基酯的高区域选择性串联 N-烷基化/叶立德缩合反应。硫基团提高了导向叶立德缩合反应的区域选择性，为 3-氨基-2-吡喃酮的合成提供了一种新方法。
