Tether Angela L, Laverty Garry, Puga Alberto V, Seddon Kenneth R, Gilmore Brendan F, Kelly Stephen A
The QUILL Research Centre, School of Chemistry and Chemical Engineering, Queen's University Belfast BT9 5AG UK.
Biofunctional Nanomaterials Group, School of Pharmacy, Queen's University Belfast BT9 7BL UK.
RSC Adv. 2020 Jun 16;10(39):22864-22870. doi: 10.1039/d0ra03107k.
Ionic liquids (ILs) have been employed as potentially environmentally friendly replacements for harmful organic solvents, but have also been studied for their use in bioelectrochemical applications, such as in microbial electrochemistry for bioenergy production, or in industrial biocatalysis. For these processes, low microbial toxicity is important and there is a growing need for microbial toxicology studies for novel ILs. In this study, we report initial toxicity data for novel ILs, based on azepanium and 3-methylpiperidinium cations. Agar disc diffusion assays are used, along with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) determinations, to obtain rapid and inexpensive initial toxicity data for these novel ILs against and . Many of the novel ILs characterised possess low microbial toxicity relative to well-studied ILs, highlighting their potential for further study in applications where this is a desirable property.
离子液体（ILs）已被用作有害有机溶剂的潜在环境友好替代品，并且也被研究用于生物电化学应用，例如用于生物能源生产的微生物电化学，或用于工业生物催化。对于这些过程，低微生物毒性很重要，并且对新型离子液体进行微生物毒理学研究的需求日益增长。在本研究中，我们报告了基于氮杂环庚烷鎓和3-甲基哌啶鎓阳离子的新型离子液体的初始毒性数据。使用琼脂圆盘扩散试验以及最低抑菌浓度（MIC）和最低杀菌浓度（MBC）测定，以获得这些新型离子液体对[具体微生物1]和[具体微生物2]的快速且廉价的初始毒性数据。相对于经过充分研究的离子液体，许多已表征的新型离子液体具有低微生物毒性，这突出了它们在具有这种理想特性的应用中进行进一步研究的潜力。
