Beng Timothy K, Farah Abdikani Omar, Shearer Victoria
Department of Chemistry, Central Washington University Ellensburg WA 98926 USA
RSC Adv. 2020 Oct 7;10(61):37153-37160. doi: 10.1039/d0ra06619b.
A modular and functional group-tolerant protocol for the transition metal-free coupling of novel ,- and ,-heterocyclic vinyl chlorides with terminal acetylenes and styrenes has been developed, leading to the epimerization-free synthesis of fully carbofunctionalized dihydro-1,4-oxazines/thiazines. Bicyclic morpholines have also been prepared through the interrogation of newly synthesized cross-conjugated dienes in Diels-Alder reactions. The use of environmentally benign reaction media endows the current strategy with a practical advantage.
已开发出一种模块化且官能团耐受性好的方案，用于新型α-和β-杂环氯乙烯与末端乙炔和苯乙烯的无过渡金属偶联，从而实现全碳官能化二氢-1,4-恶嗪/噻嗪的无差向异构化合成。还通过在狄尔斯-阿尔德反应中研究新合成的交叉共轭二烯制备了双环吗啉。使用环境友好的反应介质赋予了当前策略实际优势。
