Rajaie Seyede Hamide, Soltani Sepideh, Yazdanpanah Zeinab, Zohrabi Tayebeh, Beigrezaei Sara, Mohseni-Takalloo Sahar, Kaviani Mojtaba, Forbes Scott C, Baker Julien S, Salehi-Abargouei Amin
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, PO Code, Yazd, 8915173160, Iran.
Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Qual Life Res. 2022 Nov;31(11):3123-3137. doi: 10.1007/s11136-022-03146-7. Epub 2022 May 6.
Obesity and related co-morbidities lead to a decrease in health-related quality of life (HRQOL) and mood. Lifestyle strategies may improve these outcomes. However, the efficacy of exercise in conjunction with a weight-loss diet on HRQOL and mood is unclear. The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to examine whether the addition of exercise to energy-restricted dietary programs improves HRQOL and mood status when compared with energy-restricted diets alone in overweight and obese adults.
Eligible RCTs were identified by searching PubMed/MEDLINE, EMBASE, ISI (Web of sciences), Scopus, and Google Scholar up to April 2021. Summary effects were derived using a random-effects model. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology.
The meta-analysis revealed that an energy-restricted diet plus exercise compared with an energy-restricted diet alone had no significant effects on depression (n = 6, hedges'g = - 0.04, 95% CI: - 0.28,0.20), MOS 36-Item Short-Form Health Survey (SF-36)-physical component summary scores (n = 8, weighted mean difference (WMD) = 1.51, 95% CI: - 0.16, 3.18), SF36-mental component summary scores (n = 7, WMD = 0.64, 95% CI: - 1.00, 2.28), and HRQOL disease-specific questionnaire scores (n = 5, hedges'g = 0.16, 95% CI: - 0.09, 0.40). The GRADE revealed that the quality of evidence was low for disease-specific HRQOL scores, and depression status; and high for physical and mental health assessed by SF-36.
In our sample of overweight and obese adults, no beneficial effect of adding exercise to an energy-restricted diet was found in terms of HRQOL and Depression.
肥胖及相关合并症会导致健康相关生活质量（HRQOL）下降和情绪问题。生活方式干预策略或许能改善这些状况。然而，运动结合减肥饮食对HRQOL和情绪的效果尚不清楚。本随机对照试验（RCT）的系统评价和荟萃分析旨在探讨，与单纯能量限制饮食相比，在超重和肥胖成年人的能量限制饮食方案中加入运动是否能改善HRQOL和情绪状态。
通过检索截至2021年4月的PubMed/MEDLINE、EMBASE、ISI（科学网）、Scopus和谷歌学术搜索符合条件的RCT。采用随机效应模型得出汇总效应。使用推荐分级评估、制定和评价（GRADE）方法评估证据质量。
荟萃分析显示，与单纯能量限制饮食相比，能量限制饮食加运动对抑郁（n = 6，Hedges'g = -0.04，95%CI：-0.28,0.20）、MOS 36项简短健康调查（SF-36）-身体成分汇总得分（n = 8，加权平均差（WMD）= 1.51，95%CI：-0.16,3.18）、SF36-心理成分汇总得分（n = 7，WMD = 0.64，95%CI：-1.00,2.28）以及HRQOL疾病特异性问卷得分（n = 5，Hedges'g = 0.16，95%CI：-0.09,0.40）均无显著影响。GRADE显示，疾病特异性HRQOL得分和抑郁状态的证据质量低；而SF-36评估的身心健康证据质量高。
在我们的超重和肥胖成年人样本中，在能量限制饮食中加入运动对HRQOL和抑郁方面未发现有益效果。
