通过脱水吡喃酮高效制备坎格列净。
Efficient Route to Canagliflozin via Anhydroketopyranose.
机构信息
API R&D, IPDO, Dr. Reddy's Laboratories Ltd., Bachupally, Hyderabad, Telangana 500090, India.
Department of Chemistry, GITAM University, Rudraram, Hyderabad, Telangana 502329, India.
出版信息
Org Lett. 2022 May 20;24(19):3450-3454. doi: 10.1021/acs.orglett.2c00980. Epub 2022 May 6.
PMID:35522756
Abstract
The development of an efficient route for the synthesis of Canagliflozin is reported. The anhydroketopyranose intermediate was isolated as a novel intermediate, which was used to prepare Canagliflozin API in high purity.
摘要
报道了一种高效合成坎格列净的路线。分离出脱水酮吡喃糖中间体作为新型中间体，用于高纯度制备坎格列净原料药。
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