iPSC 模型预测先天性心脏病的疾病结局。
iPSC model of congenital heart disease predicts disease outcome.
机构信息
Department of Pediatrics (Cardiology) and Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Department of Pediatrics (Cardiology) and Cardiovascular Institute, Stanford University, Stanford, CA, USA.
出版信息
Cell Stem Cell. 2022 May 5;29(5):659-660. doi: 10.1016/j.stem.2022.04.010.
PMID:35523134
Abstract
In this issue of Cell Stem Cell, Xu et al. demonstrate that induced pluripotent stem cell-derived cardiomyocytes from patients with hypoplastic left heart syndrome exhibit mitochondrial dysfunction and can be used for disease modeling. In addition, they show the potential to predict future heart failure and develop therapies.
摘要
在本期《Cell Stem Cell》中，Xu 等人证明，来自左心发育不全综合征患者的诱导多能干细胞衍生的心肌细胞存在线粒体功能障碍，可用于疾病建模。此外，它们还有望用于预测未来的心衰并开发治疗方法。
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