Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada.
Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada; Department of Psychology, University of Toronto, Toronto, ON, Canada.
Neuron. 2022 Jul 20;110(14):2215-2241. doi: 10.1016/j.neuron.2022.04.009. Epub 2022 May 5.
Pediatric brain tumor treatments have a high success rate, but survivors are at risk of cognitive sequelae that impact long-term quality of life. We summarize recent clinical and animal model research addressing pathogenesis or evaluating candidate interventions for treatment-induced cognitive sequelae. Assayed interventions encompass a broad range of approaches, including modifications to radiotherapy, modulation of immune response, prevention of treatment-induced cell loss or promotion of cell renewal, manipulation of neuronal signaling, and lifestyle/environmental adjustments. We further emphasize the potential of neuroimaging as a key component of cross-translation to contextualize laboratory research within broader clinical findings. This cross-translational approach has the potential to accelerate discovery to improve pediatric cancer survivors' long-term quality of life.
儿科脑肿瘤的治疗成功率很高，但幸存者有认知后遗症的风险，这会影响他们的长期生活质量。我们总结了最近的临床和动物模型研究，这些研究针对发病机制或评估治疗引起的认知后遗症的候选干预措施。经过测试的干预措施包括放射治疗的修改、免疫反应的调节、预防治疗引起的细胞损失或促进细胞更新、神经元信号的操纵以及生活方式/环境的调整。我们进一步强调神经影像学的潜力，它是将实验室研究置于更广泛的临床发现背景下的关键组成部分。这种跨翻译方法有可能加速发现，从而提高儿科癌症幸存者的长期生活质量。
