胎儿脐膨出综合征阴茎结构和发育的研究。
Study of Penis Structure and Development in Fetus With Prune Belly Syndrome.
机构信息
Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
出版信息
Urology. 2022 Aug;166:283-288. doi: 10.1016/j.urology.2022.04.017. Epub 2022 May 4.
OBJECTIVE
To evaluate the influence of prune belly syndrome (PBS) on the development of penises in human fetuses.
METHODS
We studied 39 human fetuses (including 4 with PBS) aged 11-22 weeks post conception. We measured the length and width of the free portion and penis root and the penis total length (PTL). In 21 fetuses of the control group and in 3 with PBS we analyze the penile with histochemical and immunohistochemical methods. The total penile area, area of corpora cavernosa, area of corpus spongiosum, and thickness of tunica albuginea were measured by stereological method. Means were compared using the Kolmogorov-Smirnov and ANOVA test (P <.05).
RESULTS
We did not observe difference in PTL (P = .999) when we compared the control group (4.69-29.77 mm, mean = 16.2 mm; SD = 6.34 mm) with the PBS (12.23-23 mm, mean = 16.16; SD = 4.99). The total penile area (P = .002), the area of corpora cavernosa (P = .023) and the area of corpus spongiosum (P = .004) had a significant increase when comparing the PBS with the control group.
CONCLUSION
In fetuses with PBS there is no change in the length of the penis but we observed a low rate of growth in all the other histologic parameters analyzed, suggesting that PBS impacts the penile development.
目的
评估梅干腹综合征（PBS）对人类胎儿阴茎发育的影响。
方法
我们研究了 39 个人类胎儿（包括 4 例 PBS 胎儿），这些胎儿的胎龄为 11-22 周。我们测量了游离部和阴茎根部的长度和宽度以及阴茎总长度（PTL）。在 21 例对照组胎儿和 3 例 PBS 胎儿中，我们通过组织化学和免疫组织化学方法分析了阴茎。通过体视学法测量了阴茎的总横截面积、海绵体部横截面积、海绵体部横截面积和白膜厚度。使用 Kolmogorov-Smirnov 和 ANOVA 检验（P <.05）比较平均值。
结果
我们比较了对照组（4.69-29.77mm，均值=16.2mm；标准差=6.34mm）和 PBS 组（12.23-23mm，均值=16.16；标准差=4.99）的 PTL 时，未发现差异（P=.999）。当我们比较 PBS 组与对照组时，阴茎的总横截面积（P=.002）、海绵体部横截面积（P=.023）和海绵体部横截面积（P=.004）均有显著增加。
结论
在 PBS 胎儿中，阴茎的长度没有变化，但我们观察到所有其他组织学参数的生长速度较低，这表明 PBS 影响了阴茎的发育。
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