胰岛素与年轻非胰岛素依赖型糖尿病患者循环中的单核细胞及红细胞的结合。

Insulin binding to circulating monocytes and erythrocytes in patients with non-insulin-dependent diabetes in the young.

作者信息

Naidoo C, Jialal I, Dunn R D, Govender T, Joubert S M

出版信息

Diabetes Res. 1987 Jan;4(1):35-8.

Abstract

125I-insulin binding to circulating monocytes and erythrocytes was carried out in 9 patients with non-insulin-dependent diabetes in the young (NIDDY), who belonged to families in which non-insulin-dependent diabetes was transmitted through 3 generations. The diabetics had a decreased mean maximum specific binding to monocytes 2.1 (1.1-4.1%) compared to 4.0 (2.6-6.2%) in their age, sex and weight matched reference subjects. This decreased binding was primarily due to a decrease in receptor number as all diabetics had normal affinity values (2-10 ng/ml). We have attributed the decreased binding in NIDDY to the down regulatory effect of the basal hyperinsulinemia (23.6 +/- 3.2 vs 11.7 +/- 0.5 microU/ml). By contrast the maximum specific binding to erythrocyte was similar in both groups (9.7 +/- 0.5; 8.9 +/- 0.5%; p greater than 0.5).

摘要

对9名患有青年非胰岛素依赖型糖尿病（NIDDY）的患者进行了¹²⁵I-胰岛素与循环单核细胞和红细胞的结合实验，这些患者来自非胰岛素依赖型糖尿病已三代相传的家族。与年龄、性别和体重匹配的对照受试者相比，糖尿病患者单核细胞的平均最大特异性结合降低，为2.1（1.1 - 4.1%），而对照受试者为4.0（2.6 - 6.2%）。这种结合降低主要是由于受体数量减少，因为所有糖尿病患者的亲和力值均正常（2 - 10 ng/ml）。我们将NIDDY中结合降低归因于基础高胰岛素血症的下调作用（23.6 ± 3.2对11.7 ± 0.5 μU/ml）。相比之下，两组中红细胞的最大特异性结合相似（9.7 ± 0.5；8.9 ± 0.5%；p＞0.5）。