Laboratory for Reproductive and Developmental Disorders, Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Bathinda, 151401, India.
Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Bathinda, 151401, India.
Endocrine. 2022 Jun;76(3):509-525. doi: 10.1007/s12020-022-03063-2. Epub 2022 May 6.
In this review, epi/genetic mutations of IGF-axis components associated with growth disorders have been summarized alongwith assessment of relevant diagnostic and therapeutic technology through patent literature.
PROSPERO protocol registration CRD42021279468. For scientific literature search Literature databases (PubMed, EMBASE, ScienceDirect, and Google Scholar) were queried using the appropriate syntax. Various filters were applied based on inclusion and exclusion criteria. Search results were further refined by two authors for finalizing studies to be included in this synthesis. For patent documents search Patent databases (Patentscope and Espacenet) were queried using keywords: IGF or IGFBP. Filters were applied according to International Patent Classification (IPC) and Cooperative Patent Classification (CPC). Search results were reviewed by two authors for inclusion in the patent landscape report.
For scientific literature analysis, out of 545 search results, 196 were selected for review based on the inclusion criteria. For Patent literature search, out of 485 results, 37 were selected for this synthesis.
Dysregulation of IGF-axis components leads to various abnormalities and their key role in growth and development suggests epi/mutations or structural defects among IGF-axis genes can be associated with growth disorders and may explain some of the idiopathic short stature cases. Trend of patent filings indicate advent of recombinant technology for therapeutics.
本综述总结了与生长障碍相关的 IGF 轴成分的表观/遗传突变，并通过专利文献评估了相关诊断和治疗技术。
PROSPERO 方案注册 CRD42021279468。科学文献检索 使用适当的语法在文献数据库（PubMed、EMBASE、ScienceDirect 和 Google Scholar）中查询文献数据库。根据纳入和排除标准应用各种过滤器。两位作者进一步对搜索结果进行了细化，以确定要纳入本综合研究的研究。专利文献检索 使用关键字“IGF 或 IGFBP”在专利数据库（Patentscope 和 Espacenet）中查询。根据国际专利分类（IPC）和合作专利分类（CPC）应用过滤器。两位作者对搜索结果进行了审查，以纳入专利全景报告。
对于科学文献分析，在 545 个搜索结果中，根据纳入标准选择了 196 个进行综述。对于专利文献检索，在 485 个结果中，选择了 37 个进行本综合研究。
IGF 轴成分的失调导致各种异常，其在生长和发育中的关键作用表明 IGF 轴基因中的表观/结构缺陷可能与生长障碍有关，并可能解释一些特发性身材矮小病例。专利申请趋势表明重组技术治疗的出现。
