From the Division of Allergy and Immunology, Department of Chest Diseases, Hacettepe University School of Medicine, Ankara, Turkey.
Department of Allergy and Clinical Immunology, Başakşehir Çam ve Sakura City Hospital, Istanbul, Turkey; and.
Allergy Asthma Proc. 2022 May 1;43(3):220-225. doi: 10.2500/aap.2022.43.220012.
Pollen hypersensitivity might be a determining factor for other nonseasonal allergens because it may indicate deviation of the immune system toward T-helper type 2 activity and immunoglobulin E sensitivity. To investigate whether timothy grass pollen allergy may be a predictive factor for cat sensitization and whether there is an association between sensitivity to both allergens. A retrospective review was made of patients with symptoms of rhinitis. The skin-prick test results and cat ownership status of the patients were analyzed. On the basis of the skin-prick test results with Phleum pratense (timothy grass) and other pollens, the patients were analyzed in two groups: "timothy allergic" and "non-timothy allergic." A total of 383 patients with the diagnosis of rhinitis were included in the study, which comprised 213 (55.6%) in the timothy allergic group and 170 (44.4%) in the non-timothy allergic group. The frequency of cat sensitization was significantly higher in the patients in the timothy allergic group compared with those without timothy grass allergy (33.8% versus 12.3%; p < 0.001). No significant difference was determined between the two groups in terms of cat ownership (p = 0.63). In the logistic regression analysis, cat ownership (adjusted odds ratio [OR] 23.07 [95% confidence interval {CI}, 7.72-68.91]) and timothy allergy (adjusted OR 7.72 [95% CI, 3.16-18.86]) were associated with an increased risk of cat sensitization. Timothy grass allergy may play a role in the development of cat sensitization; however, further research is needed to clarify these associations and the underlying mechanisms.
花粉过敏可能是其他非季节性过敏原的决定因素，因为它可能表明免疫系统向辅助性 T 细胞 2 型活性和免疫球蛋白 E 敏感性发生偏离。为了研究豚草花粉过敏是否可能是猫过敏致敏的预测因素，以及两种过敏原之间是否存在关联。对有鼻炎症状的患者进行了回顾性研究。分析了患者的皮肤点刺试验结果和猫的拥有情况。根据豚草（豚草）和其他花粉的皮肤点刺试验结果，将患者分为“豚草过敏”和“非豚草过敏”两组。共有 383 例诊断为鼻炎的患者纳入本研究，其中豚草过敏组 213 例（55.6%），非豚草过敏组 170 例（44.4%）。豚草过敏组患者猫过敏的发生率明显高于非豚草过敏组（33.8%对 12.3%；p<0.001）。两组之间猫的拥有情况无显著差异（p=0.63）。在逻辑回归分析中，猫的拥有（调整后优势比[OR]23.07[95%置信区间{CI}7.72-68.91]）和豚草过敏（调整后 OR 7.72[95% CI 3.16-18.86]）与猫过敏致敏的风险增加相关。豚草过敏可能在猫过敏致敏的发生中起作用；然而，需要进一步研究来阐明这些关联和潜在机制。
