From the Department of Medicine, Rutgers Robert Wood Johnson Medical Center, Allergy Partners of New Jersey, Ocean, New Jersey.
Department of Medicine, Jersey Shore University Medical Center, Allergy Partners of New Jersey, Ocean, New Jersey.
Allergy Asthma Proc. 2022 May 1;43(3):178-186. doi: 10.2500/aap.2022.43.220014.
Eosinophilic esophagitis (EoE) is a Type-2 chronic inflammatory food antigen-driven disease of the esophagus, characterized by eosinophilic predominant inflammation and a constellation of symptoms. The incidence and prevalence of EoE has increased over the past 2 decades. There is an unmet need for approved less burdensome treatment options. To describe the underlying pathophysiology and diagnosis of EoE and discuss the currently available treatment options. We also aim to review the new and emerging therapies for EoE. A search of a medical literature data base was performed for articles that discuss treatment for EoE. A comparison of current therapies showed that dietary elimination, swallowed topical corticosteroids, and proton-pump inhibitor therapy are all effective for different populations. Emerging therapies that were reviewed include new topical corticosteroids and biologics directed against Type 2 inflammation. EoE is a chronic inflammatory disorder that can be debilitating, with long-term sequelae. There are no current approved therapies in the United States. Numerous new treatments are on the horizon. Increasing amounts of data are helping to tailor treatment for each patient. Ultimately, shared decision-making is the best approach to guide treatment choices with patients to manage the ever-increasing burden of this disease.
嗜酸细胞性食管炎（EoE）是一种 2 型慢性炎症性食物抗原驱动的食管疾病，其特征是嗜酸性粒细胞为主的炎症和一系列症状。在过去的 20 年中，EoE 的发病率和患病率有所增加。目前需要批准负担更小的治疗选择。本文旨在描述 EoE 的潜在病理生理学和诊断，并讨论目前可用的治疗选择。我们还旨在综述 EoE 的新出现的治疗方法。对讨论 EoE 治疗的医学文献数据库进行了检索。对现有治疗方法的比较表明，饮食消除、口服局部皮质类固醇和质子泵抑制剂治疗对不同人群均有效。综述中包括针对 2 型炎症的新型局部皮质类固醇和生物制剂等新兴疗法。EoE 是一种慢性炎症性疾病，可能会使人衰弱，长期存在后遗症。目前在美国没有批准的治疗方法。许多新的治疗方法即将出现。越来越多的数据有助于针对每位患者量身定制治疗方案。最终，共同决策是指导患者治疗选择的最佳方法，以应对这种疾病不断增加的负担。
