Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Institute of Chemistry, The Minerva Center for Bio-hybrid Complex Systems, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
Angew Chem Int Ed Engl. 2022 Aug 1;61(31):e202205758. doi: 10.1002/anie.202205758. Epub 2022 Jun 15.
Light offers unique opportunities for controlling the activity of materials and biosystems with high spatiotemporal resolution. Molecular photoswitches are chromophores that undergo reversible isomerization between different states upon irradiation with light, allowing a convenient means to control their influence over the system of interest. However, a significant limitation of classical photoswitches is the requirement to initiate the switching in one or both directions using deleterious UV light with poor tissue penetration. Red-shifted photoswitches are hence in high demand and have attracted keen recent research interest. In this Review, we highlight recent progress towards the development of visible- and NIR-activated photoswitches characterized by distinct photochromic reaction mechanisms. We hope to inspire further endeavors in this field, allowing the full potential of these tools in biotechnology and materials chemistry applications to be realized.
光具有独特的机会，可实现具有高时空分辨率的材料和生物系统的活性控制。分子光开关是发色团，在受到光照射时在不同状态之间发生可逆异构化，从而提供了一种方便的手段来控制它们对感兴趣的系统的影响。然而，经典光开关的一个显著限制是需要使用穿透力差的有害 UV 光来启动一个或两个方向的切换。因此，对红移光开关的需求很高，并引起了最近的研究兴趣。在这篇综述中，我们强调了可见光和近红外光激活光开关的最新进展，这些光开关具有不同的光致变色反应机制。我们希望激发该领域的进一步努力，使这些工具在生物技术和材料化学应用中的全部潜力得以实现。
