Center for Nephrology "G. Papadakis", General Hospital of Nikaia-Piraeus "Agios Panteleimon", 18454, Piraeus, Nikaia, Greece.
Department of Internal Medicine, University of Ioannina, 45110, Ioannina, Greece.
High Blood Press Cardiovasc Prev. 2022 Jul;29(4):367-374. doi: 10.1007/s40292-022-00522-9. Epub 2022 May 7.
Uric acid (UA) is a risk factor associated with cardiometabolic diseases. However, the appropriate threshold of UA remains a matter of controversy.
To assess whether slightly increased UA levels have any significance in middle-aged, treatment-naïve persons with new-onset hypertension.
In this cross-sectional study we recruited middle-aged participants with new-onset hypertension who were treatment-naïve. Subjects below (Group 1) and above the median UA levels (Group 2) were compared regarding clinical and laboratory characteristics that are implicated in cardiovascular and renal risk. The study population consisted of 369 persons (mean age 48.4±10 years) with median UA of 4.8 mg/dl. Group 2 individuals were predominantly male and had higher levels of blood pressure, increased body mass index, waist circumference, and a greater degree of insulin resistance. Additionally, greater lipid profile abnormalities were detected. This group also exhibited a significantly decreased fractional excretion of UA. Multivariate analysis demonstrated that serum UA levels were correlated with male sex, waist circumference, estimated glomerular filtration rate (eGFR), serum calcium and insulin levels, as well as with fractional excretion of UA. A positive association between serum UA levels and the number diagnostic criteria of the metabolic syndrome (MtS) was also noticed. After reclassification of subjects according to UA quartiles, individuals with UA levels ≥ 3.8 mg/dl had significantly higher odds (2.5-fold to 9.8-fold) of having MtS after adjustment of age, sex, and eGFR.
Uric acid levels in middle-aged, treatment-naïve hypertensive patients are correlated with risk factors for cardiovascular and renal disease.
尿酸（UA）是与心脏代谢疾病相关的风险因素。然而，UA 的适当阈值仍存在争议。
评估新诊断高血压的中年未经治疗的患者中尿酸水平略有升高是否有意义。
在这项横断面研究中，我们招募了新诊断为高血压且未经治疗的中年参与者。比较了 UA 水平低于（第 1 组）和高于中位数（第 2 组）的受试者在心血管和肾脏风险相关的临床和实验室特征方面的差异。研究人群由 369 名（平均年龄 48.4±10 岁）患者组成，UA 的中位数为 4.8 mg/dl。第 2 组患者主要为男性，血压水平较高，体重指数、腰围增加，胰岛素抵抗程度更严重。此外，还发现血脂异常更为严重。该组的 UA 排泄分数也明显降低。多变量分析表明，血清 UA 水平与性别、腰围、估算肾小球滤过率（eGFR）、血清钙和胰岛素水平以及 UA 排泄分数有关。还注意到血清 UA 水平与代谢综合征（MtS）的诊断标准数量之间存在正相关。根据 UA 四分位数重新对受试者进行分类后，UA 水平≥3.8 mg/dl 的个体在调整年龄、性别和 eGFR 后，患有 MtS 的几率显著更高（2.5 倍至 9.8 倍）。
中年未经治疗的高血压患者的尿酸水平与心血管和肾脏疾病的危险因素相关。
