Mazze R S, Lucido D, Langer O, Hartmann K, Rodbard D
Diabetes Care. 1987 Jan-Feb;10(1):111-7. doi: 10.2337/diacare.10.1.111.
Sixty-nine individuals with diabetes (23 with type I, 15 with pregestational, and 31 with gestational) used specially modified reflectance meters containing memory chips enabling the instruments to store 440 individual blood glucose values with corresponding time and date. These data were organized into 14-day periods and then collapsed into a graphic depiction, the Ambulatory Glucose Profile (AGP), which was represented as the pattern of the 25th, 50th, and 75th percentiles of blood glucose values. These three curves illustrate the median level of control and provide an index of variability in control at each hour of a "typical day." We observed distinctive AGPs related to the variability in metabolic control and the type of diabetes. Comparisons between diagnostic groups showed consistent differences between groups, independent of level of glycemic control. Review of serial AGPs obtained for sequential 2-wk periods for 23 non-pregnant individuals with type I diabetes and 10 women with gestational diabetes revealed changes in AGP corresponding to alterations in regimen. The AGP provides a new approach to the evaluation of glycemic control, with applications to patient and physician education, clinical investigation, and individual patient care.
69名糖尿病患者（23名I型糖尿病患者、15名孕前糖尿病患者和31名妊娠期糖尿病患者）使用了经过特殊改装的反射仪，这些反射仪装有存储芯片，能够存储440个个体血糖值以及相应的时间和日期。这些数据被整理成14天的时间段，然后汇总成一种图形描述，即动态血糖图谱（AGP），它表示为血糖值的第25、50和75百分位数的模式。这三条曲线说明了控制的中位数水平，并提供了“典型一天”中每个小时控制变异性的指标。我们观察到与代谢控制变异性和糖尿病类型相关的独特AGP。诊断组之间的比较显示，各组之间存在一致的差异，与血糖控制水平无关。对23名非妊娠I型糖尿病患者和10名妊娠期糖尿病女性连续2周的连续AGP进行回顾，发现AGP的变化与治疗方案的改变相对应。AGP为血糖控制评估提供了一种新方法，可应用于患者和医生教育、临床研究以及个体患者护理。
