Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medical & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Int Immunopharmacol. 2022 Aug;109:108733. doi: 10.1016/j.intimp.2022.108733. Epub 2022 May 4.
Microglia are the earliest activated and the longest lasting immune cells after stroke, and they participate in almost all the pathological reactions after stroke. However, their regulatory mechanism has not been fully elucidated. Triggering receptor expressed on myeloid cells-2 (TREM2) is a cell surface receptor that is mainly expressed in microglia of the central nervous system. The receptor plays an important role in regulating microglia energy metabolism and phenotypic transformation. At present, TREM2 has been developed as a potential target for AD, coronary atherosclerosis and other diseases. However, TREM2 does not provide a systematic summary of the functional transformation and intrinsic molecular mechanisms of microglia after stroke. In this paper, we have summarized the functional changes of TREM2 in microglia after stroke in recent years, and found that TREM2 has important effects on energy metabolism, phagocytosis and anti-inflammatory function of microglia after stroke, suggesting that TREM2 is a potential therapeutic target for the treatment of stroke.
小胶质细胞是中风后最早被激活和持续时间最长的免疫细胞，它们参与中风后几乎所有的病理反应。然而，它们的调节机制尚未完全阐明。髓样细胞触发受体 2（TREM2）是一种细胞表面受体，主要表达在中枢神经系统的小胶质细胞中。该受体在调节小胶质细胞能量代谢和表型转化方面发挥着重要作用。目前，TREM2 已被开发为 AD、冠状动脉粥样硬化等疾病的潜在治疗靶点。然而，TREM2 并没有对中风后小胶质细胞的功能转化和内在分子机制进行系统总结。本文总结了近年来 TREM2 在中风后小胶质细胞中的功能变化，发现 TREM2 对中风后小胶质细胞的能量代谢、吞噬作用和抗炎功能有重要影响，提示 TREM2 是治疗中风的潜在治疗靶点。
