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Clinical considerations for DPD deficiency testing in advanced cancer patients: tumor lysis syndrome should be considered as a major interference.

作者信息

Launay M, Guitton J, Balluet R, Moreau A, Phelip J-M, Tholance Y, Gonzalo P

机构信息

Laboratory of Pharmacology, Toxicology and Blood Gazes, University Hospital of Saint Etienne, Saint Etienne.

Laboratory of Pharmacology and Toxicology, Lyon-Sud University Hospital-Hospices Civil de Lyon, Lyon.

出版信息

Ann Oncol. 2022 Aug;33(8):850-852. doi: 10.1016/j.annonc.2022.04.073. Epub 2022 May 5.

DOI:10.1016/j.annonc.2022.04.073
PMID:35525375
Abstract
摘要

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1
Clinical considerations for DPD deficiency testing in advanced cancer patients: tumor lysis syndrome should be considered as a major interference.晚期癌症患者二氢嘧啶脱氢酶（DPD）缺乏检测的临床考量：肿瘤溶解综合征应被视为主要干扰因素。
Ann Oncol. 2022 Aug;33(8):850-852. doi: 10.1016/j.annonc.2022.04.073. Epub 2022 May 5.
2
Evaluation of predictive tests for screening for dihydropyrimidine dehydrogenase deficiency.二氢嘧啶脱氢酶缺陷筛查预测试验的评估。
Pharmacogenomics J. 2013 Oct;13(5):389-95. doi: 10.1038/tpj.2013.25. Epub 2013 Jul 16.
3
Dihydropyrimidine dehydrogenase deficiency, a pharmacogenetic syndrome associated with potentially life-threatening toxicity following 5-fluorouracil administration.二氢嘧啶脱氢酶缺乏症，一种与5-氟尿嘧啶给药后潜在危及生命的毒性相关的药物遗传学综合征。
Clin Colorectal Cancer. 2004 Sep;4(3):181-9. doi: 10.3816/ccc.2004.n.018.
4
[Dihydropyrimidine déhydrogenase (DPD) deficiency screening and securing of fluoropyrimidine-based chemotherapies: Update and recommendations of the French GPCO-Unicancer and RNPGx networks].[二氢嘧啶脱氢酶（DPD）缺乏症筛查与基于氟嘧啶的化疗保障：法国GPCO-法国国立癌症研究所联盟和RNPGx网络的更新与建议]
Bull Cancer. 2018 Apr;105(4):397-407. doi: 10.1016/j.bulcan.2018.02.001. Epub 2018 Feb 24.
5
Depressed hepatic dihydropyrimidine dehydrogenase activity and fluorouracil-related toxicities.肝脏二氢嘧啶脱氢酶活性降低与氟尿嘧啶相关毒性。
Am J Med. 1995 Dec;99(6):685-8. doi: 10.1016/s0002-9343(99)80259-9.
6
Current insights into the impact of dihydropyrimidine dehydrogenase deficiency in patients receiving treatment with 5-fluorouracil.当前对接受5-氟尿嘧啶治疗的患者中二氢嘧啶脱氢酶缺乏症影响的见解。
Clin Adv Hematol Oncol. 2016 Jul;14(7):510-2.
7
[Requirement of DPD deficiency screening before prescription of fluoropyrimidines].[氟嘧啶类药物处方前进行二氢嘧啶脱氢酶（DPD）缺乏筛查的要求]
Bull Cancer. 2018 Apr;105(4):331-332. doi: 10.1016/j.bulcan.2018.03.001.
8
[Review of methods for determination of dihydropyrimidine dehydrogenase and possible application in screening previous chemotheraphy with 5-fluorouracil].[二氢嘧啶脱氢酶测定方法的综述及其在5-氟尿嘧啶既往化疗筛查中的可能应用]
Przegl Lek. 2012;69(9):694-7.
9
Prevention of 5-fluorouracil-induced early severe toxicity by pre-therapeutic dihydropyrimidine dehydrogenase deficiency screening: Assessment of a multiparametric approach.通过治疗前二氢嘧啶脱氢酶缺乏症筛查预防5-氟尿嘧啶引起的早期严重毒性：多参数方法的评估
Semin Oncol. 2017 Feb;44(1):13-23. doi: 10.1053/j.seminoncol.2017.02.008. Epub 2017 Feb 11.
10
Artificial increase of uracilemia during fluoropyrimidine treatment can lead to DPD deficiency misinterpretation.氟嘧啶治疗期间人为增加尿嘧啶血症可导致对二氢嘧啶脱氢酶缺乏症的误诊。
Ann Oncol. 2021 Jun;32(6):810-811. doi: 10.1016/j.annonc.2021.02.020. Epub 2021 Mar 1.

引用本文的文献

1
Trifluridine- and tipiracil-induced DPD inhibition mimicking DPD deficiency: a case report.三氟尿苷和替匹嘧啶诱导的二氢嘧啶脱氢酶抑制模拟二氢嘧啶脱氢酶缺乏：一例报告
Front Oncol. 2025 Aug 12;15:1591120. doi: 10.3389/fonc.2025.1591120. eCollection 2025.
2
Plasma clearance of 5-fluorouracil is more influenced by variations in glomerular filtration rate than by uracil concentration.5-氟尿嘧啶的血浆清除率受肾小球滤过率变化的影响大于受尿嘧啶浓度的影响。
Cancer Chemother Pharmacol. 2024 Dec 19;95(1):9. doi: 10.1007/s00280-024-04732-x.
3
Renal impairment and abnormal liver function tests in pre-therapeutic phenotype-based DPD deficiency screening using uracilemia: a comprehensive population-based study in 1138 patients.
在使用尿血症进行基于治疗前表型的二氢嘧啶脱氢酶（DPD）缺乏症筛查中肾功能损害和肝功能检查异常：一项针对1138例患者的基于人群的综合研究
Ther Adv Med Oncol. 2023 Jan 10;15:17588359221148536. doi: 10.1177/17588359221148536. eCollection 2023.
4
Quantitative impact of pre-analytical process on plasma uracil when testing for dihydropyrimidine dehydrogenase deficiency.分析前过程对二氢嘧啶脱氢酶缺陷检测时血浆尿嘧啶定量影响。
Br J Clin Pharmacol. 2023 Feb;89(2):762-772. doi: 10.1111/bcp.15536. Epub 2022 Oct 3.