Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, POB 21, FI-00014 Helsinki, Finland.
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Biol Psychol. 2022 May;171:108345. doi: 10.1016/j.biopsycho.2022.108345. Epub 2022 May 5.
Major depression is associated with alterations in the auditory P3 event-related potential (ERP). However, the persistence of these abnormalities after recovery from depressive episodes, especially in young adults, is not well known. Furthermore, the potential influence of substance use on this association is poorly understood. Young adult twin pairs (N = 177) from the longitudinal FinnTwin16 study were studied with a psychiatric interview, and P3a and P3b ERPs elicited by task-irrelevant novel sounds and targets, respectively. Dyadic linear mixed-effect models were used to distinguish the effects of lifetime major depressive disorder from familial factors and effects of alcohol problem drinking and tobacco smoking. P3a amplitude was significantly increased and P3b latency decreased, in individuals with a history of lifetime major depression, when controlling the fixed effects of alcohol abuse, tobacco, gender, twins' birth order, and zygosity. These results suggest that past lifetime major depressive disorder may be associated with enhanced attentional sensitivity.
重度抑郁症与听觉 P3 事件相关电位（ERP）的改变有关。然而，人们对抑郁发作后这些异常的持续存在，尤其是在年轻人中，知之甚少。此外，物质使用对这种关联的潜在影响也知之甚少。本研究使用任务无关的新声音和目标分别诱发 P3a 和 P3b ERP，对来自纵向 FinnTwin16 研究的青年双胞胎（N=177）进行了精神科访谈。使用二元线性混合效应模型来区分终生重度抑郁症的影响与家族因素以及酒精问题饮酒和吸烟的影响。在控制酒精滥用、烟草、性别、双胞胎出生顺序和同卵性的固定效应后，有终生重度抑郁症病史的个体的 P3a 振幅显著增加，P3b 潜伏期缩短。这些结果表明，过去的终生重度抑郁症可能与增强的注意力敏感性有关。
