tau蛋白聚集

Tau Aggregation.

作者信息

Hernández Félix, Ferrer Isidro, Pérez Mar, Zabala Juan Carlos, Del Rio Jose Antonio, Avila Jesús

机构信息

Centro de Biología Molecular 'Severo Ochoa' (CBMSO) CSIC/UAM, Madrid, Spain.

Department of Pathology and Experimental Therapeutics, University of Barcelona, Bellvitge, University Hospital-IDIBELL, Hospitalet de Llobregat, Spain; Department of Cell Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, 08028 Barcelona, Spain.

出版信息

Neuroscience. 2023 May 10;518:64-69. doi: 10.1016/j.neuroscience.2022.04.024. Epub 2022 May 4.

DOI:10.1016/j.neuroscience.2022.04.024

PMID:35525497

Abstract

Here we revisit tau protein aggregation at primary, secondary, tertiary and quaternary structures. In addition, the presence of non-aggregated tau protein, which has been recently discovered, is also commented on.

摘要

在这里，我们重新审视tau蛋白在一级、二级、三级和四级结构上的聚集情况。此外，还对最近发现的非聚集态tau蛋白的存在进行了评论。